Accute Toxicity Of Extract From Melinjo (Gnetum Gnemon L) Leaf With Fixed Dose Procedure Method

Melinjo leaves has several benefits as antidiabetic, antihyperglycemia, antioxidant and diuretic. In this experiment the acute toxicity test of ethanol extract melinjo (Gnetum gnemon L). on male white rats wistar strain with fixed dose procedure method. The result screening phytochemical showed that beluntas contained alcaloid, flavonoid, saponin, fenolic, tanin. Ethanol was obtained by maceration using 70%. From observational study, 2000 mg/kg BW chosen starting for main study. Experimental animal subject used in study were 10 which divided into 2 group, normal group treatment a mg/kgBW. there no death or sign all experimental animals. During 14 days observation period, significant changes body weight either control treatmen (p>0.05). had effect macroscopic organs liver, kidneys heart animals average level biochemical parameters is SGOT 54.13±11.428 U/L, SGPT 47.476±21.655 creatinine 0.632±0.199 mg/dL, urea 14.46±2.267 while 60.192±14.198 55.968±22.998 0.756±0.204 16±2.561 mg/dL. It mg/kgBW are category practically non-toxic.